在斑馬魚孕產婦Nanoplastics轉移到後代(鮐魚類):一個案例研究Nanopolystyrene

塑料是無處不在的人為汙染物在水生環境中越來越多的關注。macroplastics汙染的生態影響都被記錄在案,但是nanoplastics所知甚少。目前的研究調查nanoplastics的潛在不利影響,這可能導致塑料汙染的生態負擔。為此,我們研究了膳食暴露是否成年斑馬魚(鮐魚類),聚苯乙烯納米粒子(PS NPs)可能導致轉移nanoplastics後代,以及是否nanoplastics暴露影響斑馬魚生理學。具體來說,成年女性和男性斑馬魚(F0代)暴露在PS NPs通過飲食一周和培育產生F1代。四個F1組生成:控製(未暴露的女性和男性),孕產婦(暴露的女性),父親(接觸男性)和co-parental(男性和女性接觸)。Co-parental PS NP接觸並沒有顯著影響的生殖成功。評估組織的F0魚透露,暴露在PS NPs顯著減少穀胱甘肽還原酶活動的大腦,肌肉,和睾丸,但並不影響線粒體在心髒或性腺功能參數。F1的胚胎和幼蟲的評估表明,PS NPs存在於卵黃囊、胃腸道、肝髒和胰腺的母親般地coparentally暴露F1胚胎/幼蟲。心動過緩也觀察胚胎從孕產婦和co-parental暴露組。 In addition, the activity of glutathione reductase and the levels of thiols were reduced in F1 embryos/ larvae from maternal and/or co-parental exposure groups.Mitochondrial function and locomotor activity were not affected in F1 larvae. This study demonstrates that (i) PS NPs are transferred from mothers to offspring, and (ii) exposure to PS NPs modifies the antioxidant system in adult tissues and F1 larvae. We conclude that PS NPs could bioaccumulate and be passed on to the offspring, but this does not lead to major physiological disturbances.